Authors

Dr. David Fajgenbaum is the cofounder and President of Every Cure, as well as an Associate Professor of Medicine at the University of Pennsylvania, the Founding Director of the Center for Cytokine Storm Treatment & Laboratory, the Associate Director of Patient Impact at the Penn Orphan Disease Center, and the cofounder and President of the Castleman Disease Collaborative Network. He’s one of the youngest faculty members ever tenured at Penn’s Perelman School of Medicine, one of the youngest awardees of multiple National Institutes of Health (NIH) grants in the US and currently serves on the Board of Directors for the Reagan-Udall Foundation for the FDA. Known for his research into Castleman disease, a disease he became critically ill with while he was in medical school, when he was told there were no more options for treatment, he repurposed immunosuppressant used after kidney transplants and saved his own life. He has since been directly involved in repurposing 14 treatments, and brings the experience of living with a deadly, rare disease to his work.
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September 8, 2025
TED
How nearly dying helped me discover my own cure (and many more)
Physician-scientist David Fajgenbaum was dying from a rare disease that didn't have a cure — until he discovered a lifesaving drug that wasn't originally intended for his condition. In an astonishing talk, he shares how his near-death experience led him to cofound the nonprofit Every Cure, which is using AI to uncover hidden treatments in existing medicines in order to save lives. (This ambitious idea is part of The Audacious Project, TED’s initiative to inspire and fund global change.)